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First, the removal of genes indiscriminately expressed by astrocytes to retain their cytoarchitectural and fundamental signaling layouts (for example, S100b ) or to encode their generic functions (for example, neurotransmitter metabolism and uptake ( EAAT1,2 , Adcyap1 , Glul , Aqp4 and Slc38a3 ), syncytial connectivity ( Gja1 ), energy metabolism ( Apoe , Aldh1l1 and Aldoc ) and trophic factors ( Ntrk2 , Egfr and Fgf3 ) eliminates stability bias